COVID S1RBD interacts with hACE2

Yu-Yuan (Stuart) Yang | Feb 17, 2025 min read

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Summary of the Research Paper on SARS-CoV-2 Omicron Variants

  • The study investigates the spike protein and hACE2 interface of SARS-CoV-2 omicron variants, focusing on hydrogen bond formation.
  • It highlights the rapid spread of the omicron variant and its subvariants, which became dominant in early 2022.
  • Molecular dynamics simulations were performed to analyze the structural features and interactions of various variants, revealing increased hydrogen-bond interactions in omicron variants.
  • The research provides insights into the transmissibility of these variants and their evolutionary trends.

Know more from reference…

  1. Yang, Y. Y. and Tseng, Y. J. (May 2023). “The evolution of SARS-CoV-2 Omicron Variants on the spike-protein and hACE2 interface – determined by the hydrogen bonding formations.” Briefings in Functional Genomics, DOI: 10.1093/bfgp/elac053
  2. Yang, Y. Y. and Tseng, Y. J. “Competitive analysis of different SARS-CoV-2 variants in United Kingdom, Israel, South Africa, Brazil and Peru.” American Chemical Society (ACS) Spring 2022. (virtual, 20–24 Mar.)